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Modalert Canada

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Modalert Canada
#1
En bloquant ces récepteurs, le modafinil provoque une augmentation des niveaux des neurotransmetteurs noradrénaline, dopamine et sérotonine. En 2006, Cephalon a acquis le droit mondial de commercialiser le modafinil à des fins thérapeutiques. Le modafinil affecte principalement le SNC et il n'est pas recommandé chez les personnes souffrant de maladies cardiovasculaires, d'arythmies, d'hypertension ou d'insuffisance hépatique. Le modafinil est considéré comme un traitement sûr et efficace contre la somnolence diurne excessive. En termes d'action au niveau du LC, deux résultats ont suggéré une implication directe : premièrement, l'hypothalamus antérieur, qui reçoit des projections efférentes du LC, s'est avéré réduit en taille avec le traitement au modafinil ; deuxièmement, une augmentation des courants post-synaptiques inhibiteurs spontanés a été détectée dans les neurones LC avec un traitement au modafinil. Modalert Canada Il n'est structurellement identique à aucun des neurotransmetteurs endogènes dopamine ou sérotonine, et on pense qu'il partage ses effets dans le SNC en interagissant avec des protéines impliquées dans les systèmes endogènes de dopamine et de sérotonine du cerveau. Le modafinil est approuvé pour le traitement des personnes atteintes de deux affections, la narcolepsie et les troubles du sommeil liés au travail posté. Les personnes qui prennent ce médicament doivent consulter leur médecin avant la grossesse. Il est disponible sous forme de produit générique en comprimés à dose unique sous les noms de marque Provigil, Nu-Modafinil et R-Modafinil. Une capsule contenant du modafinil est disponible, mais n'est pas une formulation typique utilisée dans les études sur son efficacité. Une dose maximale est de 400 à 800 mg par jour. Le modafinil est également un antagoniste des récepteurs de la dopamine. Pour compenser cela, l'amphétamine et d'autres précurseurs et inhibiteurs de la dopamine tels que le méthylphénidate sont administrés simultanément avec le modafinil. On ne sait pas s'ils sont dose-dépendants. Pour éviter l'induction du sommeil à partir d'une dose de 300 mg, trois à quatre jours doivent être autorisés entre les doses. Il existe peu d'informations sur les effets à long terme de l'utilisation de Modafinil. Les enfants, les adolescents et les femmes enceintes ont un risque élevé d'effets indésirables graves. Le modafinil a été développé par le neuroscientifique français Michel Jouvet dans les années 1970, spécifiquement pour les personnes souffrant de somnolence diurne excessive (EDS) associée à la narcolepsie.

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#2
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#3
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#4
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#5
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