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Modiodal
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Modiodal
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Le modafinil semble agir sur le cortex, l'amygdale, le systГЁme limbique et les ganglions de la base dans le cerveau. Dans ce cas, le groupe tiers sous licence avait prГ©parГ© une demande auprГЁs de la FDA pour commercialiser le modafinil de maniГЁre gГ©nГ©rique et l'agence a constatГ© l'innocuitГ© et l'efficacitГ© d'une utilisation en tant qu'amplificateur cognitif. Le modafinil est utilisГ© pour traiter l'hypersomnie chronique idiopathique. Les effets pharmacologiques du modafinil ont Г©tГ© Г©tudiГ©s chez l'animal et chez l'homme. Le modafinil a une demi-vie relativement courte d'environ 4 heures, en raison de la dГ©gradation de la molГ©cule de modafinil par mГ©thylation, hydroxylation et glucuronidation ultГ©rieure. Il a Г©tГ© dГ©montrГ© que le modafinil amГ©liore les performances, la vigilance et l'Г©veil. Pour cette raison, il est recommandГ© de commencer Modafinil avec une faible dose et de surveiller Г©troitement le pouls et la pression artГ©rielle. Modiodal L'effet du modafinil sur les voies sГ©rotoninergiques est bloquГ© par un traitement combinГ© par un inhibiteur de la recapture de la sГ©rotonine et de la noradrГ©naline (IRSN) (par exemple la venlafaxine). L'adГ©nosine est un neurotransmetteur qui se lie normalement aux rГ©cepteurs cellulaires du cerveau et qui rend les cellules plus actives et libГЁre de la dopamine. Le modafinil est une poudre cristalline blanche qui peut ГЄtre prise par voie orale. La dose approuvГ©e de modafinil est de 200 mg. Modulation du systГЁme sГ©rotoninergique Le modafinil agit comme un stimulant du systГЁme nerveux central, d'abord dans le locus coeruleus du cerveau, puis dans les parties plus distales du cerveau, amГ©liorant l'activitГ© du systГЁme sГ©rotoninergique. Le modafinil augmente indirectement la libГ©ration de dopamine en augmentant la sГ©crГ©tion des hormones hormone corticotrope (ACTH) et cortisol, qui Г leur tour stimulent la synthГЁse et la sГ©crГ©tion de dopamine. De rares rГ©actions allergiques graves peuvent survenir, y compris l'anaphylaxie. De par son profil pharmacologique, et contrairement Г l'acГ©tylcholine, le Modafinil produit ses effets sans provoquer de surstimulation de son rГ©cepteur. Cette recherche, cependant, a fait l'objet d'un examen minutieux car aucun des essais n'Г©tait contrГґlГ© par placebo. Le modafinil est un libГ©rateur de dopamine avec des effets similaires Г l'amphГ©tamine ; ses actions antipsychotiques pourraient ГЄtre dues Г ce mГ©canisme d'action. Il est dГ©conseillГ© aux femmes enceintes. La formulation typique de modafinil contient 200 mg ou 400 mg. Ses effets durent gГ©nГ©ralement de 10 Г 12 heures.
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10-24-2023, 10:22 PM
(This post was last modified: 10-24-2023, 11:08 PM by wyrmrider.)
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