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Actuellement, le modafinil est le seul médicament approuvé par la FDA aux États-Unis pour le traitement de la narcolepsie, de la cataplexie et des troubles du sommeil liés au travail posté. Il est plus souvent utilisé pour aider les gens à rester éveillés pendant le travail posté ou pour lutter contre la somnolence due à l'apnée obstructive du sommeil. Le médicament a été rapidement supprimé de l'utilisation dans la clinique française après seulement quelques années et a pu être acheté sur le marché des médicaments en France. Des expériences sur de jeunes animaux dans des zoos et des laboratoires n'ont pas montré qu'il produisait des effets à long terme, comme dans des études dans lesquelles des animaux sont chargés d'une tâche pour voir s'il y a une différence dans leurs performances ultérieures. Il agit plus lentement chez les personnes souffrant d'apnée obstructive du sommeil que chez celles qui n'en ont pas. Modiodal La solubilité du chlorhydrate de modafinil est de 15 mg/ml dans l'eau et de 3 mg/ml dans l'éthanol. Le modafinil s'est également avéré avoir une activité sur le système nerveux central similaire à la caféine et à la nicotine. Le modafinil a été approuvé aux États-Unis par la Food and Drug Administration (FDA) le 23 septembre 1998 pour le traitement de la somnolence diurne excessive associée à la narcolepsie, aux troubles du sommeil liés au travail posté et à l'apnée obstructive du sommeil. Aux États-Unis, le modafinil est un médicament délivré uniquement sur ordonnance et a une catégorie de grossesse D de la FDA. Il est commercialisé comme contre-mesure de la fatigue et de la somnolence chez les personnes ayant un travail posté chronique. Le médicament doit être pris à jeun et sans nourriture dans l'estomac. Cette stimulation est bloquée par blocage. Les effets secondaires les plus courants sont les troubles du sommeil, les maux de tête, les problèmes de concentration, les nausées et l'insomnie. Les doses maximales sont de 400 mg par jour avec jusqu'à six gélules par jour et de 400 mg après minuit avec jusqu'à 12 gélules par jour. Le médicament doit être pris avec les repas pour diminuer le risque de nausées. C'est le prix le plus bas que nous ayons pu trouver pour le Modafinil 100 mg au Royaume-Uni. De rares réactions dermatologiques graves peuvent survenir chez les personnes présentant des prédispositions génétiques et plus fréquemment chez les patients pédiatriques. Il peut augmenter les niveaux de dopamine dans des régions spécifiques du cerveau, en particulier dans les zones impliquées dans la cognition.

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