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Modiodal Drogue
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Modiodal Drogue
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Certaines Г©tudes suggГЁrent que le modafinil pourrait ГЄtre efficace pour amГ©liorer la somnolence non liГ©e au quart de travail causГ©e par l'insomnie d'endormissement. Le modafinil est Г©galement utilisГ© hors AMM pour gГ©rer les symptГґmes de troubles tels que l'hypersomnie idiopathique, oГ№ la somnolence diurne est le seul symptГґme. Le modafinil est structurellement similaire Г l'amphГ©tamine, mais a un indice de similaritГ© chimique (CSI) de 0,2. Le modafinil peut permettre aux horaires de sommeil des travailleurs postГ©s de s'adapter plus facilement Г leurs rythmes circadiens. Cependant le prix peut diffГ©rer. Le modafinil est vendu par Sigma Aldrich sous forme de comprimГ©s dispersibles de 100 mg. Modiodal Drogue Le modafinil a Г©galement un effet central possible sur l'acide gamma-aminobutyrique (GABA), similaire Г l'effet d'autres benzodiazГ©pines. Il n'est pas approuvГ© pour une utilisation Г cette fin chez les enfants, mais certains mГ©decins le prescrivent pour des problГЁmes de sommeil mineurs chez les enfants et les adolescents et chez les Г©tudiants. Le modafinil peut fonctionner en stimulant les neurones dopaminergiques dans la rГ©gion tegmentale ventrale du cerveau ainsi que le cortex frontal, le cortex cingulaire et le cervelet. Il peut ГЄtre trГЁs variable. On ne sait pas quels sont ses effets exacts sur le corps, et certains d'entre eux n'ont pas Г©tГ© entiГЁrement compris. Cette action a Г©tГ© remarquГ©e pour la premiГЁre fois chez les animaux et n'a Г©tГ© confirmГ©e que maintenant chez l'homme. En comparant le dosage, la dose de 150 mg est la mГЄme que celle de 200 mg, et toutes deux infГ©rieures Г celles de 400 mg. Les enfants sont plus susceptibles de ressentir plus d'effets indГ©sirables lors de l'utilisation de la version gГ©nГ©rique. MГ©canisme d'action : le modafinil est un stimulant du SNC qui agit pour favoriser l'Г©veil en augmentant les niveaux d'AMPc dans les neurones. Une dose de 200 Г 400 mg, selon les individus, peut ГЄtre prise en deux prises fractionnГ©es. C'est une poudre blanche Г blanc cassГ© avec un goГ»t d'amande amГЁre. En doses quotidiennes, il est pris sous forme de 1-2 comprimГ©s de 100 mg.
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