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Acheter Provigil Generique
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Il est indiquГ© pour le traitement Г court terme de la somnolence excessive associГ©e Г la narcolepsie avec ou sans cataplexie, les troubles du sommeil liГ©s au travail postГ©, la somnolence diurne excessive associГ©e Г l'apnГ©e obstructive du sommeil, et pour prГ©venir la nГ©cessitГ© d'utiliser des mГ©dicaments pour traiter ou prГ©venir une telle somnolence. Le modafinil est plus sГ©lectif pour la recapture de la sГ©rotonine et de la noradrГ©naline par rapport Г la dopamine. Il agit sur le mГЄme rГ©cepteur de dopamine que les amphГ©tamines, stimulant les rГ©cepteurs de dopamine D1 et D2. Le modafinil est un mГ©dicament d'ordonnance qui peut ГЄtre pris quotidiennement. Le modafinil a Г©galement Г©tГ© lancГ© pour le traitement des troubles du sommeil liГ©s au travail postГ© en 2005. Acheter Provigil Generique Le cerveau produit de la dopamine et le neurotransmetteur sГ©rotonine. Le modafinil est absorbГ© par les muqueuses de la cavitГ© buccale, mais pas Г travers la peau. Il a Г©tГ© brevetГ© en 1976 et a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Le modafinil est parfois appelГ© Provigil, ProvГ©dia et chlorhydrate de modafinil. Le modafinil est gГ©nГ©ralement pris lorsque vous commencez Г vous sentir fatiguГ©. Aux Г‰tats-Unis, les noms de marque du mГ©dicament incluent Provigil, Armodafinil et Nuvigil. Il est considГ©rГ© comme un inhibiteur partiel de la neurotransmission de la dopamine et est Г©galement un agoniste allostГ©rique du rГ©cepteur alpha-2A. Le modafinil peut ГЄtre efficace pour ces patients car il agit en augmentant la pulsion de sommeil, tandis que d'autres somnifГЁres ciblent l'instabilitГ© du sommeil. L'Г©nantiomГЁre unique s'est avГ©rГ© efficace dans les Г©tudes animales ainsi que chez l'homme. Les transporteurs de norГ©pinГ©phrine et de dopamine sont Г©galement utilisГ©s pour la recapture de la sГ©rotonine, de sorte que le systГЁme de recapture de la sГ©rotonine peut ГЄtre affectГ©. D'autres mГ©canismes incluent le blocage des rГ©cepteurs noradrГ©nergiques alpha-2 (utilisГ©s pour le sommeil) et des rГ©cepteurs histaminergiques H1 (qui sont impliquГ©s dans l'Г©veil du sommeil). Les cellules dopaminergiques avec des niveaux Г©levГ©s de rГ©cepteurs pour le modafinil sont prГ©sentes dans tout le cerveau mais sont relativement dГ©ficientes dans les glandes surrГ©nales. Ses effets sont mГ©diГ©s par le systГЁme nerveux dans son ensemble, et non par une partie spГ©cifique de celui-ci. Chez des volontaires sains, le modafinil a considГ©rablement augmentГ© le nombre d'erreurs lorsque les participants ont Г©tГ© testГ©s sur le test des capacitГ©s cognitives de Woodcock-Johnson.
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