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Modafinil Europe
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Modafinil Europe
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La biodisponibilitГ© moyenne de 200 mg de modafinil est d'environ 50 %. Le modafinil est excrГ©tГ© principalement sous forme inchangГ©e via la bile, l'urine et les fГЁces. C'est peut-ГЄtre une faГ§on dont la cafГ©ine agit dans le cafГ©. Des Г©tudes ont montrГ© que Modafinil est peu susceptible d'interagir avec des mГ©dicaments qui ne sont pas mГ©tabolisГ©s dans le foie, tels que les inhibiteurs de la MAO. Il a Г©galement Г©tГ© utilisГ© pour traiter certains symptГґmes du trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH). Par exemple, les enfants et les adolescents qui en prennent pour la narcolepsie nГ©cessitent une dose plus Г©levГ©e que les adultes. Modafinil Europe Le modafinil (SILD-101) est une phГ©nГ©thylamine synthГ©tique produite sous la forme d'un mГ©lange racГ©mique de deux Г©nantiomГЁres. Avant d'ГЄtre approuvГ© pour la vente aux Г‰tats-Unis, le Modafinil n'Г©tait disponible que sous forme de mГ©dicament sur ordonnance fabriquГ© en France par Concert Pharmaceuticals (plus tard Cephalon, Inc. Le modafinil est un stimulant du systГЁme nerveux central (SNC) utilisГ© pour traiter la somnolence due Г la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. Le modafinil est un mГ©dicament dГ©rivГ© de l'acide aminГ© tyrosine. Ces preuves prГ©liminaires sont basГ©es sur des Г©tudes ouvertes (Г©tudes sans bras placebo). La dose habituelle de modafinil pour les enfants est de 100 Г 200 mg/jour. Le modafinil a Г©galement un effet anti-cholinergique, ce qui indique qu'il agit Г©galement sur des types spГ©cifiques de rГ©cepteurs de l'acГ©tylcholine, et a Г©galement indirectement un effet inhibiteur sur la sГ©rotonine. L'adГ©nosine est un neurotransmetteur aux propriГ©tГ©s sГ©datives et le modafinil semble augmenter son seuil d'excitation. De nombreux mГ©dicaments sont mГ©tabolisГ©s par ces enzymes, et ce sont les interactions mГ©dicamenteuses potentielles les plus probables. Un comitГ© consultatif de la FDA en 2013 a trouvГ© des preuves Г l'appui de son utilisation comme amГ©liorateur de performance diurne, avec la mise en garde qu'il pourrait ne pas ГЄtre efficace chez les personnes souffrant de troubles du sommeil. Le modafinil agit en diminuant la latence d'endormissement, en augmentant la vigilance et en rГ©duisant la somnolence matinale. Le modafinil est prescrit aux patients souffrant de somnolence chronique. Alors que les Г©tudes animales suggГЁrent que le modafinil est un inducteur d'Г©veil plus efficace que la cafГ©ine, on ne sait pas si cela est vrai chez l'homme.
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