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Nootropique En Pharmacie
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Nootropique En Pharmacie
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Le modafinil affecte les systГЁmes dopaminergiques (associГ©s au plaisir, au mouvement et Г la pensГ©e) ainsi que les systГЁmes adГ©nosine, sГ©rotonine et GABA du cerveau. Les patients doivent ГЄtre Г©troitement surveillГ©s s'ils prennent ce mГ©dicament avec de l'alcool ou avec des mГ©dicaments sГ©datifs-hypnotiques. Cette action provoque la libГ©ration de neurotransmetteurs tels que la noradrГ©naline et la dopamine. Modafinil est disponible sous plusieurs formes. Il a Г©tГ© suggГ©rГ© que cet effet est le plus prononcГ© dans le cortex prГ©frontal. Chez les personnes atteintes de narcolepsie et d'autres hypersomnies, la modulation de la fonction dopaminergique cГ©rГ©brale semble favoriser l'Г©veil et Г©liminer les symptГґmes d'endormissement et les symptГґmes liГ©s au sommeil paradoxal. De faibles doses augmentent gГ©nГ©ralement l'Г©veil, tandis que des doses Г©levГ©es augmentent la somnolence. Les effets secondaires rares et graves peuvent inclure des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Le modafinil a Г©tГ© utilisГ© hors AMM comme activateur cognitif. Ces effets secondaires sont susceptibles d'ГЄtre plus frГ©quents chez les enfants, les adolescents et les personnes atteintes de tumeurs cГ©rГ©brales. Les effets pharmacologiques du modafinil sont mГ©diГ©s par les autorГ©cepteurs alpha-1 et alpha-2. Le mГ©canisme d'action du modafinil est similaire Г celui de l'amphГ©tamine. Nootropique En Pharmacie Le modafinil est un agoniste indirect de la dopamine, c'est-Г -dire un agoniste du rГ©cepteur de la dopamine qui se lie au rГ©cepteur D1. On ne sait pas si l'utilisation pendant la grossesse est sans danger. Il a Г©tГ© dГ©montrГ© que le modafinil amГ©liore les performances cognitives chez les rats dans certains contextes, bien qu'il ne semble pas amГ©liorer les performances chez les singes. Le modafinil est un stimulant du SNC. Le modafinil est classГ© comme agent sympathomimГ©tique et est un agent favorisant l'Г©veil. Un stimulant est dГ©fini comme un mГ©dicament qui augmente la vigilance, la concentration et/ou la production d'autres humeurs. Des effets psychiatriques indГ©sirables ont Г©tГ© rapportГ©s, notamment agitation, dГ©pression, pensГ©es suicidaires ou violentes, activitГ© sociale et sexuelle excessive et hostilitГ©. Le modafinil a Г©galement un goГ»t trГЁs agrГ©able qui facilite la prise d'une dose. Il est Г©galement disponible sous forme de comprimГ© Г libГ©ration retardГ©e de 150 mg, de comprimГ© Г libГ©ration prolongГ©e de 200 mg et de comprimГ© Г libГ©ration prolongГ©e de 100 mg. Cependant, il a Г©tГ© dГ©montrГ© qu'il amГ©liore un certain nombre de fonctions liГ©es au sommeil et Г l'Г©veil, notamment la vigilance, l'attention, la mГ©moire et les fonctions exГ©cutives.
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