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Modiodal Modafinil
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Modiodal Modafinil
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Il se lie aux rГ©cepteurs couplГ©s aux protГ©ines G stimulantes, GPR137 et GPR173. Chez la souris, il a Г©tГ© dГ©montrГ© que le modafinil stimule le cortex prГ©frontal ainsi que le locus coeruleus dans le cerveau et augmente l'activation des neurones dopaminergiques, un effet qui semble ГЄtre plus fort chez la souris sur une plus longue pГ©riode de temps. La biodisponibilitГ© du modafinil est d'environ 85 %. Les personnes souffrant de narcolepsie perdent souvent leur sens du temps et de l'espace et perdent la capacitГ© de se souvenir des expГ©riences rГ©centes. L'activitГ© accrue des cellules cГ©rГ©brales libГЁre de la sГ©rotonine. Il est gГ©nГ©ralement utilisГ© comme somnifГЁre. Modiodal Modafinil Cela peut rГ©duire la qualitГ© du sommeil de certaines personnes. En 1998, il a Г©tГ© approuvГ© par la Food and Drug Administration (FDA) des Г‰tats-Unis pour une utilisation comme traitement de la somnolence excessive associГ©e Г la narcolepsie. Le modafinil est le seul stimulant du SNC approuvГ© par la FDA amГ©ricaine pour le traitement de la somnolence excessive associГ©e Г la narcolepsie. L'absorption d'une dose orale unique de modafinil est rapide et les concentrations plasmatiques maximales sont atteintes environ une heure aprГЁs l'administration. Il n'y a pas de doses d'entretien recommandГ©es. Il a Г©tГ© dГ©veloppГ© pour fonctionner comme un agent favorisant l'Г©veil pour lutter contre la somnolence. Le modafinil est Г©galement approuvГ© pour le traitement de la somnolence excessive chez les patients souffrant de narcolepsie ou d'apnГ©e obstructive du sommeil (OSA), et pour le traitement de la somnolence excessive chez les patients souffrant d'hypersomnie idiopathique. Le modafinil a Г©tГ© approuvГ© pour une utilisation chez les personnes atteintes de narcolepsie Г des doses de 150 Г 200 mg, et il s'agit d'une substance contrГґlГ©e de l'annexe IV aux Г‰tats-Unis. Le modafinil n'induit pas d'Г©lГ©vation de l'humeur par lui-mГЄme, mais fonctionne plutГґt comme un agent favorisant l'Г©veil, et les effets d'autres stimulants peuvent ГЄtre facilitГ©s. On ne sait pas lesquels des mГ©canismes d'action du modafinil sont responsables de ses propriГ©tГ©s d'amГ©lioration cognitive. Les mГ©canismes par lesquels le modafinil affecte le cerveau ne sont toujours pas clairs, mais la recherche suggГЁre qu'il fonctionne en augmentant la libГ©ration de dopamine dans le cerveau. Il a Г©tГ© notГ© que le modafinil amГ©liore la fonction cognitive sans augmenter la stimulation physique, mentale ou psychologique. La dose initiale est de 200 mg et la dose peut ГЄtre augmentГ©e Г des intervalles de 200 mg jusqu'Г une dose quotidienne maximale de 400 mg selon les individus. La plupart des effets secondaires du Modafinil sont dus Г ses propriГ©tГ©s stimulantes. Pris de maniГЁre appropriГ©e, le modafinil est gГ©nГ©ralement sГ»r et bien tolГ©rГ©.
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