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Modafinil Ordonnance
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Modafinil Ordonnance
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Le modafinil est utilisГ© principalement pour le traitement de la somnolence excessive. Depuis, les utilisations hors AMM se sont dГ©veloppГ©es, comme en tГ©moigne cette Г©tude. Une seule Г©tude l'a trouvГ© utile pour les personnes souffrant de dГ©pression. Il est formulГ© avec l'enrobage entГ©rique Emdex ER-12. Il a Г©tГ© dГ©montrГ© qu'il a une longue demi-vie d'environ six Г neuf heures chez les personnes atteintes du polymorphisme CYP1A2. En tant que stimulant du SNC, le modafinil agit en amГ©liorant la neurotransmission dans le cerveau et le systГЁme nerveux. Modafinil Ordonnance Le modafinil peut Г©galement augmenter la sensation de vigilance pendant l'Г©veil. Les personnes qui en prennent ont tendance Г Г©prouver un sentiment initial de В« descente В». Le modafinil peut ГЄtre administrГ© en doses fractionnГ©es (premiГЁre dose de 50 mg, seconde dose de 50 mg) ou en doses uniques. Les comprimГ©s sont blancs, oblongs, brillants ou translucides et peuvent ГЄtre imprimГ©s sur le comprimГ©. L'arrГЄt est recommandГ© dГЁs les premiers signes d'Г©ruption cutanГ©e ou de rГ©actions similaires. Contrairement Г de nombreux autres stimulants du SNC, cependant, le modafinil ne provoque pas d'augmentation des niveaux d'Г©nergie, mais favorise plutГґt l'Г©veil et amГ©liore les performances. Il est prescrit en France pour le traitement de la narcolepsie. Il peut Г©galement ГЄtre utilisГ© comme traitement pour les personnes souffrant de troubles du sommeil liГ©s au travail postГ©. Le modafinil est pris par voie orale sous forme de comprimГ© ou de capsule. Les auteurs de cette derniГЁre mГ©ta-analyse ont conclu que, bien que le modafinil puisse produire une amГ©lioration cognitive chez les personnes en bonne santГ©, ce n'est pas un traitement efficace pour les troubles cognitifs. Le gГЁne du rГ©cepteur est liГ© aux rГ©cepteurs de la dopamine. Cependant, chez certaines personnes, ces effets secondaires peuvent s'aggraver et conduire Г la dГ©pression. Cela conduit Г une augmentation des concentrations de dopamine dans les zones du cerveau associГ©es Г l'Г©veil. La dose initiale habituelle recommandГ©e est de 50 mg par jour.
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