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Modiodal Generique
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Modiodal Generique
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Les neurotransmetteurs dopamine et sérotonine sont concentrés dans les zones du cerveau impliquées dans l'attention et la concentration, et le modafinil augmente la neurotransmission dans ces zones. Il est spécifiquement utilisé pour traiter les troubles impliquant un manque d'éveil, tels que les troubles du sommeil liés au travail posté ou la somnolence diurne excessive chez les personnes souffrant d'apnée obstructive du sommeil. La dose recommandée est de 100 à 200 mg à la fois, jusqu'à 400 mg par jour. Bien qu'il n'agisse pas sur les voies adrénergiques du système nerveux sympathique comme les amphétamines, il est similaire au modafinil en ce sens qu'il contribue à augmenter l'éveil. La Food and Drug Administration (FDA) a approuvé ce médicament pour le traitement de la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil. Le modafinil est une poudre cristalline blanche à blanc cassé d'un poids moléculaire de 345,60. Modiodal Generique Le modafinil est librement soluble dans l'éthanol et insoluble dans l'eau. Le modafinil est utilisé pour traiter la somnolence due à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Il agit en augmentant les niveaux de dopamine extracellulaire et augmente l'éveil. La mesure dans laquelle il le fait dépend de la dose. Le modafinil agit sur les neurones qui ont une fonction prépondérante dans l'éveil, et qui sont normalement fermés dans le sommeil. Aux États-Unis, la FDA a approuvé le modafinil sous le nom de marque Provigil. Le modafinil est excrété dans l'urine et les fèces. Le modafinil a été initialement développé en tant que produit chimique de recherche par le neuroscientifique français Michel Jouvet, et semble avoir été testé pour la première fois sur des rats, qui ont été exposés à une stimulation électrique imprévue qui aurait provoqué dans leur cerveau ce que l'on appelle des symptômes dissociatifs de type psilocybine, qui peut être ressentie par une exposition prolongée à des doses extrêmement élevées de psychédéliques comme la psilocybine. La libération de dopamine dans le cortex préfrontal pourrait être l'un des mécanismes d'action du modafinil pour traiter les troubles du sommeil liés au travail posté. Le modafinil est chimiquement connu sous le nom de 2-(diphénylméthyl)cyclopropane-méthanol et est couramment vendu sous les noms de marque Alertec, Modavigil et Provigil, entre autres. Certaines personnes peuvent éprouver d'autres effets secondaires. Le modafinil est un stimulant similaire à l'amphétamine. La forme à libération immédiate se présente également sous la forme d'un comprimé à libération retardée, vendu en gélule de 10 mg. Le modafinil est également utilisé pour certains cas d'insomnie chronique résistante aux autres thérapies.
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10-31-2023, 06:30 AM
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